/* CSF Proteomics Dementia Database - Professional Bioinformatics Style */

@import url('https://fonts.googleapis.com/css2?family=Poppins:wght@300;400;500;600;700;800;900&family=JetBrains+Mono:wght@400;500;600;700&display=swap');

:root {
    /* Modern Vibrant Color Scheme - Light Mode */
    --primary-color: #6366f1;
    --primary-dark: #4f46e5;
    --primary-light: #818cf8;
    --accent-color: #f43f5e;
    --accent-hover: #e11d48;
    --bg-color: #fafbfc;
    --bg-secondary: #ffffff;
    --card-bg: rgba(255, 255, 255, 0.85);
    --card-hover: rgba(255, 255, 255, 0.95);
    --text-primary: #0f172a;
    --text-secondary: #64748b;
    --border-color: #e2e8f0;
    --shadow-sm: 0 2px 4px rgba(0, 0, 0, 0.04);
    --shadow-md: 0 6px 12px rgba(0, 0, 0, 0.08);
    --shadow-lg: 0 12px 24px rgba(0, 0, 0, 0.12);
    --shadow-glow: 0 0 40px rgba(99, 102, 241, 0.2);
    --success-color: #10b981;
    --warning-color: #f59e0b;
    --danger-color: #ef4444;
    --info-color: #06b6d4;
    --chart-bg: #ffffff;
    --chart-grid: #e2e8f0;
    --chart-text: #0f172a;
    
    /* Gradients */
    --gradient-primary: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    --gradient-accent: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
    --gradient-bg: linear-gradient(180deg, #fafbfc 0%, #f0f4ff 100%);
    --gradient-card: linear-gradient(135deg, rgba(255, 255, 255, 0.9) 0%, rgba(255, 255, 255, 0.7) 100%);
}

/* Dark Mode */
body.dark-mode {
    --primary-color: #818cf8;
    --primary-dark: #6366f1;
    --primary-light: #a5b4fc;
    --accent-color: #fb7185;
    --accent-hover: #f43f5e;
    --bg-color: #0a0e1a;
    --bg-secondary: #151b2e;
    --card-bg: rgba(21, 27, 46, 0.85);
    --card-hover: rgba(21, 27, 46, 0.95);
    --text-primary: #f1f5f9;
    --text-secondary: #94a3b8;
    --border-color: #1e293b;
    --shadow-sm: 0 2px 4px rgba(0, 0, 0, 0.4);
    --shadow-md: 0 6px 16px rgba(0, 0, 0, 0.5);
    --shadow-lg: 0 12px 32px rgba(0, 0, 0, 0.6);
    --shadow-glow: 0 0 40px rgba(129, 140, 248, 0.3);
    --success-color: #34d399;
    --warning-color: #fbbf24;
    --danger-color: #f87171;
    --info-color: #22d3ee;
    --chart-bg: #151b2e;
    --chart-grid: #1e293b;
    --chart-text: #f1f5f9;
    
    --gradient-primary: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    --gradient-accent: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
    --gradient-bg: linear-gradient(180deg, #0a0e1a 0%, #1a1f3a 100%);
    --gradient-card: linear-gradient(135deg, rgba(21, 27, 46, 0.9) 0%, rgba(21, 27, 46, 0.7) 100%);
}

* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

body {
    font-family: 'Poppins', -apple-system, BlinkMacSystemFont, sans-serif;
    background: var(--gradient-bg);
    color: var(--text-primary);
    line-height: 1.7;
    overflow-x: hidden;
    animation: fadeInPage 0.6s ease-out;
    transition: background 0.5s cubic-bezier(0.4, 0, 0.2, 1), color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
    position: relative;
}

body::before {
    content: '';
    position: fixed;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: 
        radial-gradient(circle at 20% 30%, rgba(99, 102, 241, 0.08) 0%, transparent 50%),
        radial-gradient(circle at 80% 70%, rgba(244, 63, 94, 0.08) 0%, transparent 50%);
    pointer-events: none;
    z-index: 0;
}

body.dark-mode::before {
    background: 
        radial-gradient(circle at 20% 30%, rgba(129, 140, 248, 0.12) 0%, transparent 50%),
        radial-gradient(circle at 80% 70%, rgba(251, 113, 133, 0.12) 0%, transparent 50%);
}

@keyframes fadeInPage {
    from {
        opacity: 0;
    }
    to {
        opacity: 1;
    }
}

/* Navbar - Enhanced Glassmorphism Design */
.navbar {
    background: rgba(255, 255, 255, 0.85);
    backdrop-filter: blur(24px) saturate(180%);
    -webkit-backdrop-filter: blur(24px) saturate(180%);
    border-bottom: 1px solid rgba(226, 232, 240, 0.6);
    padding: 0.75rem 0;
    position: sticky;
    top: 0;
    z-index: 1000;
    box-shadow: 0 4px 24px rgba(0, 0, 0, 0.06), 0 0 1px rgba(0, 0, 0, 0.04);
    animation: slideDown 0.5s ease-out;
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode .navbar {
    background: rgba(21, 27, 46, 0.85);
    border-bottom: 1px solid rgba(30, 41, 59, 0.6);
    box-shadow: 0 4px 24px rgba(0, 0, 0, 0.4), 0 0 1px rgba(0, 0, 0, 0.2);
}

@keyframes slideDown {
    from {
        transform: translateY(-100%);
        opacity: 0;
    }
    to {
        transform: translateY(0);
        opacity: 1;
    }
}

.navbar .container {
    max-width: 1600px;
    margin: 0 auto;
    padding: 0 2rem;
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.navbar .logo {
    display: flex;
    align-items: center;
    gap: 1rem;
}

.navbar h1 {
    font-size: 1.3rem;
    font-weight: 800;
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    letter-spacing: -0.8px;
}

.navbar .subtitle {
    font-size: 0.7rem;
    color: var(--text-secondary);
    margin-top: 0.1rem;
    font-weight: 400;
}

.navbar .nav-links {
    display: flex;
    gap: 1.5rem;
    align-items: center;
}

.navbar .nav-links a {
    color: var(--text-secondary);
    text-decoration: none;
    font-weight: 500;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    padding: 0.4rem 0.8rem;
    border-radius: 8px;
    font-size: 0.9rem;
    position: relative;
}

.navbar .nav-links a::after {
    content: '';
    position: absolute;
    bottom: 0;
    left: 50%;
    width: 0;
    height: 2px;
    background: var(--primary-color);
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    transform: translateX(-50%);
}

.navbar .nav-links a:hover {
    color: var(--primary-color);
    background: rgba(37, 99, 235, 0.05);
}

.navbar .nav-links a:hover::after {
    width: 80%;
}

.navbar .nav-links a.active {
    color: var(--primary-color);
    background: rgba(37, 99, 235, 0.1);
}

/* Tabs - Glassmorphism Style */
.tabs-inline {
    display: flex;
    gap: 0.5rem;
    align-items: center;
}

.tabs-inline .tab {
    padding: 0.5rem 1.2rem;
    background: rgba(255, 255, 255, 0.6);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    border: 1px solid rgba(226, 232, 240, 0.8);
    border-radius: 10px;
    cursor: pointer;
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--text-secondary);
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    position: relative;
    overflow: hidden;
}

.tabs-inline .tab::before {
    content: '';
    position: absolute;
    top: 0;
    left: -100%;
    width: 100%;
    height: 100%;
    background: linear-gradient(90deg, transparent, rgba(37, 99, 235, 0.1), transparent);
    transition: left 0.5s ease;
}

.tabs-inline .tab:hover::before {
    left: 100%;
}

.tabs-inline .tab:hover {
    color: var(--primary-color);
    border-color: var(--primary-color);
    background: rgba(37, 99, 235, 0.05);
    transform: translateY(-2px);
    box-shadow: 0 4px 12px rgba(37, 99, 235, 0.15);
}

.tabs-inline .tab.active {
    color: white;
    background: var(--gradient-primary);
    border-color: transparent;
    box-shadow: 0 4px 12px rgba(37, 99, 235, 0.3);
}

/* Language Switcher - Glassmorphism */
.language-switcher {
    display: flex;
    gap: 0.3rem;
    align-items: center;
    background: rgba(255, 255, 255, 0.6);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    padding: 0.3rem;
    border-radius: 10px;
    border: 1px solid rgba(226, 232, 240, 0.8);
}

.language-switcher button {
    background: none;
    border: none;
    color: var(--text-secondary);
    cursor: pointer;
    padding: 0.4rem 0.8rem;
    border-radius: 8px;
    font-size: 0.85rem;
    font-weight: 600;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
}

.language-switcher button:hover {
    color: var(--primary-color);
    background: rgba(37, 99, 235, 0.1);
    transform: scale(1.05);
}

.language-switcher button.active {
    color: white;
    background: var(--primary-color);
    box-shadow: 0 2px 8px rgba(37, 99, 235, 0.3);
}

/* Main Container */
.container {
    max-width: 1600px;
    margin: 0 auto;
    padding: 2rem;
    position: relative;
    z-index: 1;
}

/* Tab Content with Animation */
.tab-content {
    display: none;
}

.tab-content.active {
    display: block;
    animation: fadeInUp 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

/* Search Section - Glassmorphism */
.search-section {
    background: rgba(255, 255, 255, 0.7);
    backdrop-filter: blur(20px) saturate(180%);
    -webkit-backdrop-filter: blur(20px) saturate(180%);
    padding: 3rem;
    border-radius: 24px;
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.08);
    margin-bottom: 3rem;
    border: 1px solid rgba(255, 255, 255, 0.8);
    position: relative;
    z-index: 100;
    position: relative;
    overflow: visible;
    animation: scaleIn 0.6s cubic-bezier(0.4, 0, 0.2, 1);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode .search-section {
    background: rgba(30, 41, 59, 0.7);
    border: 1px solid rgba(51, 65, 85, 0.8);
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.3);
}

@keyframes scaleIn {
    from {
        opacity: 0;
        transform: scale(0.95);
    }
    to {
        opacity: 1;
        transform: scale(1);
    }
}

.search-section::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 4px;
    background: var(--gradient-primary);
    border-radius: 24px 24px 0 0;
}

.search-section h2 {
    font-size: 1.8rem;
    margin-bottom: 1.5rem;
    color: var(--text-primary);
    font-weight: 700;
    letter-spacing: -0.5px;
}

.search-box {
    display: flex;
    gap: 1rem;
    max-width: 900px;
    position: relative;
}

.search-input {
    flex: 1;
    padding: 1.1rem 1.6rem;
    border: 2px solid var(--border-color);
    border-radius: 18px;
    font-size: 1.05rem;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    background: rgba(255, 255, 255, 0.95);
    color: var(--text-primary);
    font-family: 'JetBrains Mono', monospace;
    font-weight: 500;
}

.search-input:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: 0 0 0 5px rgba(99, 102, 241, 0.12), 0 4px 12px rgba(99, 102, 241, 0.15);
    background: white;
    transform: translateY(-3px);
}

.search-input::placeholder {
    color: var(--text-secondary);
    font-weight: 400;
}

/* Search Suggestions - Glassmorphism */
.search-suggestions {
    position: absolute;
    top: calc(100% + 0.5rem);
    left: 0;
    right: 180px;
    background: rgba(255, 255, 255, 0.95);
    backdrop-filter: blur(20px) saturate(180%);
    -webkit-backdrop-filter: blur(20px) saturate(180%);
    border: 1px solid var(--border-color);
    border-radius: 16px;
    max-height: 300px;
    overflow-y: auto;
    box-shadow: 0 12px 40px rgba(0, 0, 0, 0.12);
    z-index: 2001;
    animation: slideDownFade 0.3s cubic-bezier(0.4, 0, 0.2, 1);
}

@keyframes slideDownFade {
    from {
        opacity: 0;
        transform: translateY(-10px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

.suggestion-item {
    padding: 0.75rem 1rem;
    cursor: pointer;
    transition: all 0.2s cubic-bezier(0.4, 0, 0.2, 1);
    border-bottom: 1px solid rgba(226, 232, 240, 0.5);
    font-family: 'Fira Code', monospace;
    font-size: 0.9rem;
    color: var(--text-primary);
}

.suggestion-item:last-child {
    border-bottom: none;
}

.suggestion-item:hover {
    background: rgba(37, 99, 235, 0.08);
    color: var(--primary-color);
    padding-left: 1.5rem;
}

/* Buttons - Glassmorphism with Animation */
.btn {
    padding: 1rem 2rem;
    border: none;
    border-radius: 16px;
    font-size: 1rem;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    display: inline-flex;
    align-items: center;
    gap: 0.5rem;
    font-family: 'Outfit', sans-serif;
    position: relative;
    overflow: hidden;
}

.btn::before {
    content: '';
    position: absolute;
    top: 50%;
    left: 50%;
    width: 0;
    height: 0;
    border-radius: 50%;
    background: rgba(255, 255, 255, 0.3);
    transform: translate(-50%, -50%);
    transition: width 0.6s, height 0.6s;
}

.btn:hover::before {
    width: 300px;
    height: 300px;
}

.btn-primary {
    background: var(--gradient-primary);
    color: white;
    box-shadow: 0 4px 12px rgba(37, 99, 235, 0.3);
    position: relative;
}

.btn-primary:hover {
    transform: translateY(-3px);
    box-shadow: 0 8px 24px rgba(37, 99, 235, 0.4);
}

.btn-primary:active {
    transform: translateY(-1px);
}

/* Cards - Enhanced Glassmorphism */
.card {
    background: var(--gradient-card);
    backdrop-filter: blur(24px) saturate(180%);
    -webkit-backdrop-filter: blur(24px) saturate(180%);
    border-radius: 28px;
    padding: 2.5rem;
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.06), 0 1px 2px rgba(0, 0, 0, 0.04);
    border: 1px solid rgba(255, 255, 255, 0.6);
    margin-bottom: 2rem;
    position: relative;
    overflow: hidden;
    transition: all 0.4s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode .card {
    background: var(--gradient-card);
    border: 1px solid rgba(30, 41, 59, 0.6);
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.4), 0 1px 2px rgba(0, 0, 0, 0.2);
}

.card:hover {
    box-shadow: 0 16px 56px rgba(0, 0, 0, 0.12), 0 2px 4px rgba(0, 0, 0, 0.06);
    transform: translateY(-6px);
}

body.dark-mode .card:hover {
    box-shadow: 0 16px 56px rgba(0, 0, 0, 0.6), 0 2px 4px rgba(0, 0, 0, 0.3);
}

.card::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 4px;
    background: var(--gradient-primary);
    border-radius: 24px 24px 0 0;
}

.card h3 {
    font-size: 1.5rem;
    margin-bottom: 1.5rem;
    color: var(--text-primary);
    font-weight: 700;
    letter-spacing: -0.5px;
}

/* Volcano Grid */
.volcano-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(500px, 1fr));
    gap: 2rem;
    margin-top: 2rem;
}

.volcano-card {
    background: rgba(255, 255, 255, 0.7);
    backdrop-filter: blur(20px) saturate(180%);
    -webkit-backdrop-filter: blur(20px) saturate(180%);
    border-radius: 20px;
    padding: 1.5rem;
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.08);
    border: 1px solid rgba(255, 255, 255, 0.8);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
    cursor: pointer;
    position: relative;
    overflow: hidden;
}

body.dark-mode .volcano-card {
    background: rgba(30, 41, 59, 0.7);
    border: 1px solid rgba(51, 65, 85, 0.8);
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.3);
}

.volcano-card:hover {
    transform: translateY(-8px) scale(1.02);
    box-shadow: 0 16px 48px rgba(37, 99, 235, 0.15);
    border-color: var(--primary-color);
}

body.dark-mode .volcano-card:hover {
    box-shadow: 0 16px 48px rgba(59, 130, 246, 0.3);
}

.volcano-card h3 {
    font-size: 1.2rem;
    margin-bottom: 0.5rem;
    color: var(--text-primary);
    font-weight: 700;
    transition: color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

.volcano-card p {
    color: var(--text-secondary);
    font-size: 0.9rem;
    margin-bottom: 1rem;
    transition: color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

.volcano-placeholder {
    width: 100%;
    height: 300px;
    background: rgba(248, 250, 252, 0.5);
    border-radius: 16px;
    display: flex;
    align-items: center;
    justify-content: center;
    color: var(--text-secondary);
    font-size: 0.9rem;
    border: 2px dashed var(--border-color);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode .volcano-placeholder {
    background: rgba(15, 23, 42, 0.5);
}

.volcano-card:hover .volcano-placeholder {
    border-color: var(--primary-color);
    background: rgba(37, 99, 235, 0.03);
}

body.dark-mode .volcano-card:hover .volcano-placeholder {
    background: rgba(59, 130, 246, 0.1);
}

/* Table - Modern Professional Style */
.table-container {
    overflow-x: auto;
    border-radius: 16px;
    border: 1px solid var(--border-color);
    max-height: 350px;
    overflow-y: auto;
    background: rgba(255, 255, 255, 0.5);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode .table-container {
    background: rgba(30, 41, 59, 0.5);
}

.table-container::-webkit-scrollbar {
    width: 8px;
    height: 8px;
}

.table-container::-webkit-scrollbar-track {
    background: rgba(226, 232, 240, 0.3);
}

body.dark-mode .table-container::-webkit-scrollbar-track {
    background: rgba(51, 65, 85, 0.3);
}

.table-container::-webkit-scrollbar-thumb {
    background: var(--primary-color);
    border-radius: 4px;
}

.table-container::-webkit-scrollbar-thumb:hover {
    background: var(--primary-dark);
}

table {
    width: 100%;
    border-collapse: collapse;
    background: transparent;
}

.table-search-input {
    width: 40px;
    padding: 0.3rem;
    background: rgba(255, 255, 255, 0.8);
    border: 1px solid var(--border-color);
    border-radius: 8px;
    color: var(--text-primary);
    font-size: 0.85rem;
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
    text-align: center;
}

body.dark-mode .table-search-input {
    background: rgba(30, 41, 59, 0.8);
}

.table-search-input:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: 0 0 0 3px rgba(37, 99, 235, 0.1);
    width: 120px;
    text-align: left;
}

.table-search-input::placeholder {
    color: var(--text-secondary);
    font-size: 0.9rem;
}

thead {
    background: var(--gradient-primary);
    color: white;
    position: sticky;
    top: 0;
    z-index: 10;
}

th {
    padding: 1rem;
    text-align: left;
    font-weight: 600;
    font-size: 0.85rem;
    text-transform: uppercase;
    letter-spacing: 0.5px;
}

td {
    padding: 1rem;
    border-bottom: 1px solid rgba(226, 232, 240, 0.5);
    font-size: 0.9rem;
    font-family: 'Fira Code', monospace;
    color: var(--text-primary);
    transition: color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode td {
    border-bottom: 1px solid rgba(51, 65, 85, 0.5);
}

tbody tr {
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
}

tbody tr:hover {
    background: rgba(37, 99, 235, 0.05);
    transform: scale(1.01);
}

body.dark-mode tbody tr:hover {
    background: rgba(59, 130, 246, 0.1);
}

tbody tr:last-child td {
    border-bottom: none;
}

/* Module Grid */
.module-grid {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
    gap: 1.5rem;
    margin-top: 2rem;
}

.module-card {
    background: rgba(255, 255, 255, 0.7);
    backdrop-filter: blur(20px) saturate(180%);
    -webkit-backdrop-filter: blur(20px) saturate(180%);
    border-radius: 20px;
    padding: 1.5rem;
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.08);
    border: 1px solid rgba(255, 255, 255, 0.8);
    cursor: pointer;
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
    position: relative;
    overflow: hidden;
}

body.dark-mode .module-card {
    background: rgba(30, 41, 59, 0.7);
    border: 1px solid rgba(51, 65, 85, 0.8);
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.3);
}

.module-card::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 6px;
    background: var(--module-color, var(--primary-color));
    border-radius: 20px 20px 0 0;
}

.module-card:hover {
    transform: translateY(-8px) scale(1.03);
    box-shadow: 0 16px 48px rgba(0, 0, 0, 0.12);
    border-color: var(--module-color, var(--primary-color));
}

body.dark-mode .module-card:hover {
    box-shadow: 0 16px 48px rgba(0, 0, 0, 0.5);
}

.module-card h4 {
    font-size: 1.2rem;
    margin-bottom: 0.5rem;
    color: var(--text-primary);
    font-weight: 700;
    transition: color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

.module-card .protein-count {
    color: var(--text-secondary);
    font-size: 0.9rem;
    transition: color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

/* Badges - Modern Style with White Text on Solid Background */
.badge {
    display: inline-block;
    padding: 0.3rem 0.8rem;
    border-radius: 12px;
    font-size: 0.75rem;
    font-weight: 600;
    font-family: 'Fira Code', monospace;
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    color: white !important;
}

.badge-success {
    background: var(--success-color);
    border: 1px solid var(--success-color);
}

.badge-danger {
    background: var(--danger-color);
    border: 1px solid var(--danger-color);
}

.badge-info {
    background: var(--info-color);
    border: 1px solid var(--info-color);
}

.badge-warning {
    background: var(--warning-color);
    border: 1px solid var(--warning-color);
}

/* Stats Cards - Glassmorphism */
.stats-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 1.5rem;
    margin-bottom: 2rem;
}

.stat-card {
    background: rgba(255, 255, 255, 0.7);
    backdrop-filter: blur(20px) saturate(180%);
    -webkit-backdrop-filter: blur(20px) saturate(180%);
    padding: 1.5rem;
    border-radius: 20px;
    border: 1px solid rgba(255, 255, 255, 0.8);
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.08);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode .stat-card {
    background: rgba(30, 41, 59, 0.7);
    border: 1px solid rgba(51, 65, 85, 0.8);
    box-shadow: 0 8px 32px rgba(0, 0, 0, 0.3);
}

.stat-card:hover {
    transform: translateY(-6px) scale(1.03);
    box-shadow: 0 12px 40px rgba(37, 99, 235, 0.15);
    border-color: var(--primary-color);
}

body.dark-mode .stat-card:hover {
    box-shadow: 0 12px 40px rgba(59, 130, 246, 0.3);
}

.stat-card .stat-value {
    font-size: 2.5rem;
    font-weight: 800;
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    margin-bottom: 0.5rem;
    letter-spacing: -1px;
}

.stat-card .stat-label {
    font-size: 0.85rem;
    color: var(--text-secondary);
    text-transform: uppercase;
    letter-spacing: 0.5px;
    font-weight: 600;
    transition: color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

/* Chart Container */
.chart-container {
    width: 100%;
    height: 500px;
    margin: 1rem 0;
    background: var(--chart-bg);
    border-radius: 16px;
    padding: 1rem;
    transition: background 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

/* Line Chart Container */
.line-chart-container {
    width: 100%;
    height: 400px;
    margin: 2rem 0;
    background: var(--chart-bg);
    border-radius: 16px;
    padding: 1rem;
    transition: background 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

/* Loading Animation */
.loading {
    display: inline-block;
    width: 20px;
    height: 20px;
    border: 3px solid rgba(37, 99, 235, 0.2);
    border-radius: 50%;
    border-top-color: var(--primary-color);
    animation: spin 0.8s linear infinite;
}

@keyframes spin {
    to {
        transform: rotate(360deg);
    }
}

/* External Links */
.external-links {
    display: flex;
    gap: 1rem;
    margin: 1rem 0;
    flex-wrap: wrap;
}

.external-link {
    display: inline-flex;
    align-items: center;
    gap: 0.5rem;
    padding: 0.6rem 1.2rem;
    background: rgba(255, 255, 255, 0.7);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    border: 1px solid var(--border-color);
    border-radius: 12px;
    color: var(--primary-color);
    text-decoration: none;
    font-size: 0.9rem;
    font-weight: 600;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
}

.external-link:hover {
    background: rgba(37, 99, 235, 0.1);
    border-color: var(--primary-color);
    transform: translateY(-3px);
    box-shadow: 0 4px 12px rgba(37, 99, 235, 0.2);
}

/* Theme Switcher */
.theme-switcher {
    display: flex;
    gap: 0.3rem;
    align-items: center;
    background: rgba(255, 255, 255, 0.6);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    padding: 0.3rem;
    border-radius: 10px;
    border: 1px solid rgba(226, 232, 240, 0.8);
}

body.dark-mode .theme-switcher {
    background: rgba(30, 41, 59, 0.6);
    border: 1px solid rgba(51, 65, 85, 0.8);
}

.theme-switcher button {
    background: none;
    border: none;
    color: var(--text-secondary);
    cursor: pointer;
    padding: 0.4rem 0.8rem;
    border-radius: 8px;
    font-size: 1.2rem;
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    display: flex;
    align-items: center;
    justify-content: center;
}

.theme-switcher button:hover {
    background: rgba(37, 99, 235, 0.1);
    transform: scale(1.1);
}

.theme-switcher button.active {
    background: var(--primary-color);
    box-shadow: 0 2px 8px rgba(37, 99, 235, 0.3);
}

body.dark-mode .theme-switcher button:hover {
    background: rgba(59, 130, 246, 0.2);
}

body.dark-mode .navbar {
    background: rgba(30, 41, 59, 0.8);
    border-bottom: 1px solid rgba(51, 65, 85, 0.8);
}

body.dark-mode .tabs-inline .tab {
    background: rgba(30, 41, 59, 0.6);
    border: 1px solid rgba(51, 65, 85, 0.8);
}

body.dark-mode .language-switcher {
    background: rgba(30, 41, 59, 0.6);
    border: 1px solid rgba(51, 65, 85, 0.8);
}

/* Modal - Glassmorphism */
.modal {
    position: fixed;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: rgba(15, 23, 42, 0.6);
    backdrop-filter: blur(10px);
    -webkit-backdrop-filter: blur(10px);
    z-index: 2000;
    overflow-y: auto;
    animation: fadeIn 0.3s ease;
    transition: background 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode .modal {
    background: rgba(0, 0, 0, 0.8);
}

@keyframes fadeIn {
    from {
        opacity: 0;
    }
    to {
        opacity: 1;
    }
}

.modal-content {
    max-width: 1400px;
    margin: 2rem auto;
    background: rgba(255, 255, 255, 0.95);
    backdrop-filter: blur(30px) saturate(180%);
    -webkit-backdrop-filter: blur(30px) saturate(180%);
    border-radius: 24px;
    padding: 2rem;
    box-shadow: 0 20px 60px rgba(0, 0, 0, 0.2);
    border: 1px solid rgba(255, 255, 255, 0.8);
    position: relative;
    animation: slideUp 0.4s cubic-bezier(0.4, 0, 0.2, 1);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

body.dark-mode .modal-content {
    background: rgba(30, 41, 59, 0.95);
    border: 1px solid rgba(51, 65, 85, 0.8);
    box-shadow: 0 20px 60px rgba(0, 0, 0, 0.5);
}

@keyframes slideUp {
    from {
        opacity: 0;
        transform: translateY(50px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

.modal-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 2rem;
    padding-bottom: 1rem;
    border-bottom: 2px solid var(--border-color);
    transition: border-color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

.modal-header h2 {
    transition: color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

.modal-close {
    background: rgba(220, 38, 38, 0.1);
    border: none;
    font-size: 1.5rem;
    cursor: pointer;
    color: var(--danger-color);
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    width: 40px;
    height: 40px;
    display: flex;
    align-items: center;
    justify-content: center;
    border-radius: 12px;
    font-weight: 300;
}

.modal-close:hover {
    background: var(--danger-color);
    color: white;
    transform: rotate(90deg) scale(1.1);
}

/* Trait Correlation Cards - Professional Style */
.trait-grid {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(180px, 1fr));
    gap: 1rem;
    margin-top: 1.5rem;
}

.trait-card {
    background: rgba(255, 255, 255, 0.7);
    backdrop-filter: blur(15px) saturate(180%);
    -webkit-backdrop-filter: blur(15px) saturate(180%);
    border-radius: 16px;
    padding: 1.5rem;
    border: 2px solid var(--border-color);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
    cursor: pointer;
    position: relative;
    overflow: hidden;
}

body.dark-mode .trait-card {
    background: rgba(30, 41, 59, 0.7);
}

.trait-card::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: linear-gradient(135deg, transparent 0%, rgba(37, 99, 235, 0.05) 100%);
    opacity: 0;
    transition: opacity 0.4s ease;
}

.trait-card:hover::before {
    opacity: 1;
}

.trait-card:hover {
    transform: scale(1.15);
    z-index: 10;
    box-shadow: 0 12px 40px rgba(0, 0, 0, 0.15);
    border-color: var(--primary-color);
}

body.dark-mode .trait-card:hover {
    box-shadow: 0 12px 40px rgba(0, 0, 0, 0.5);
}

.trait-card-header {
    font-size: 0.75rem;
    color: var(--text-secondary);
    margin-bottom: 0.5rem;
    font-weight: 600;
    text-align: center;
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
    transition: color 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

.trait-card-correlation {
    font-size: 1.8rem;
    font-weight: 700;
    text-align: center;
    margin-bottom: 0.5rem;
    font-family: 'Fira Code', monospace;
}

.trait-card-stats {
    display: flex;
    justify-content: space-around;
    font-size: 0.7rem;
    color: var(--text-secondary);
    margin-top: 0.5rem;
    padding-top: 0.5rem;
    border-top: 1px solid var(--border-color);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

.trait-card-stat {
    text-align: center;
}

.trait-card-stat-label {
    font-size: 0.65rem;
    opacity: 0.7;
}

.trait-section {
    margin-bottom: 2rem;
}

.trait-section-title {
    font-size: 1.1rem;
    font-weight: 600;
    color: var(--primary-color);
    margin-bottom: 1rem;
    padding-bottom: 0.5rem;
    border-bottom: 2px solid var(--border-color);
    transition: all 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

/* Responsive Design */
@media (max-width: 1200px) {
    .tab-content {
        margin-right: 0;
    }
}

@media (max-width: 768px) {
    .container {
        padding: 1rem;
    }
    
    .navbar h1 {
        font-size: 1rem;
    }
    
    .navbar .nav-links {
        flex-wrap: wrap;
    }
    
    .volcano-grid {
        grid-template-columns: 1fr;
    }
    
    .search-box {
        flex-direction: column;
    }
    
    .module-grid {
        grid-template-columns: 1fr;
    }
    
    .search-section {
        padding: 2rem 1.5rem;
    }
}

/* Smooth Scrollbar */
::-webkit-scrollbar {
    width: 10px;
    height: 10px;
}

::-webkit-scrollbar-track {
    background: rgba(226, 232, 240, 0.3);
}

::-webkit-scrollbar-thumb {
    background: var(--primary-color);
    border-radius: 5px;
}

::-webkit-scrollbar-thumb:hover {
    background: var(--primary-dark);
}

/* Selection Style */
::selection {
    background: rgba(37, 99, 235, 0.2);
    color: var(--text-primary);
}

/* Focus Visible */
*:focus-visible {
    outline: 2px solid var(--primary-color);
    outline-offset: 2px;
}

/* Stagger Animation for Cards - Only on initial page load */
@keyframes fadeInUpStagger {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

/* Apply stagger animation only on page load, not on tab switch */
.volcano-card {
    animation: none;
}

.module-card {
    animation: none;
}

.stat-card {
    animation: none;
}

/* Only animate on first load */
body:not(.loaded) .volcano-card:nth-child(1) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.1s both; }
body:not(.loaded) .volcano-card:nth-child(2) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.2s both; }
body:not(.loaded) .volcano-card:nth-child(3) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.3s both; }
body:not(.loaded) .volcano-card:nth-child(4) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.4s both; }
body:not(.loaded) .volcano-card:nth-child(5) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.5s both; }
body:not(.loaded) .volcano-card:nth-child(6) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.6s both; }

/* Apply to all module cards */
body:not(.loaded) .module-card:nth-child(1) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.05s both; }
body:not(.loaded) .module-card:nth-child(2) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.1s both; }
body:not(.loaded) .module-card:nth-child(3) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.15s both; }
body:not(.loaded) .module-card:nth-child(4) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.2s both; }
body:not(.loaded) .module-card:nth-child(5) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.25s both; }
body:not(.loaded) .module-card:nth-child(6) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.3s both; }
body:not(.loaded) .module-card:nth-child(7) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.35s both; }
body:not(.loaded) .module-card:nth-child(8) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.4s both; }
body:not(.loaded) .module-card:nth-child(9) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.45s both; }
body:not(.loaded) .module-card:nth-child(10) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.5s both; }
body:not(.loaded) .module-card:nth-child(11) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.55s both; }
body:not(.loaded) .module-card:nth-child(12) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.6s both; }
body:not(.loaded) .module-card:nth-child(13) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.65s both; }
body:not(.loaded) .module-card:nth-child(14) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.7s both; }
body:not(.loaded) .module-card:nth-child(15) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.75s both; }
body:not(.loaded) .module-card:nth-child(16) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.8s both; }
body:not(.loaded) .module-card:nth-child(17) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.85s both; }
body:not(.loaded) .module-card:nth-child(18) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.9s both; }

body:not(.loaded) .stat-card:nth-child(1) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.1s both; }
body:not(.loaded) .stat-card:nth-child(2) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.2s both; }
body:not(.loaded) .stat-card:nth-child(3) { animation: fadeInUpStagger 0.6s cubic-bezier(0.4, 0, 0.2, 1) 0.3s both; }

/* ── ML Prediction Panel ── */
.ml-protein-grid {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(180px, 1fr));
    gap: 0.8rem;
    margin-bottom: 0.5rem;
}
.ml-protein-input-item {
    display: flex;
    flex-direction: column;
    gap: 0.3rem;
}
.ml-protein-input-item label {
    font-size: 0.8rem;
    font-weight: 600;
    color: var(--text-secondary);
    font-family: 'JetBrains Mono', monospace;
    letter-spacing: 0.02em;
}
.ml-protein-input-item input {
    padding: 0.5rem 0.7rem;
    border: 1.5px solid var(--border-color);
    border-radius: 8px;
    background: var(--bg-secondary);
    color: var(--text-primary);
    font-size: 0.9rem;
    font-family: 'JetBrains Mono', monospace;
    transition: border-color 0.2s;
    width: 100%;
    box-sizing: border-box;
}
.ml-protein-input-item input:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: 0 0 0 3px rgba(99,102,241,0.12);
}
.ml-score-display {
    display: flex;
    align-items: center;
    gap: 2rem;
    margin-bottom: 1rem;
    flex-wrap: wrap;
}
.ml-score-value {
    font-size: 3.5rem;
    font-weight: 800;
    font-family: 'JetBrains Mono', monospace;
    letter-spacing: -2px;
    line-height: 1;
}
.ml-score-bar-wrap {
    flex: 1;
    min-width: 200px;
}
.ml-score-bar-bg {
    height: 12px;
    border-radius: 6px;
    background: var(--border-color);
    overflow: hidden;
    position: relative;
}
.ml-score-bar-fill {
    height: 100%;
    border-radius: 6px;
    transition: width 0.8s cubic-bezier(0.4,0,0.2,1);
}
.ml-score-bar-threshold {
    position: absolute;
    top: -3px;
    width: 2px;
    height: 18px;
    background: #222;
    border-radius: 1px;
}
.ml-verdict {
    padding: 1rem 1.5rem;
    border-radius: 12px;
    font-size: 1.1rem;
    font-weight: 700;
    margin-bottom: 1rem;
    border-left: 5px solid;
}
.ml-verdict.positive {
    background: rgba(239,68,68,0.08);
    border-left-color: #ef4444;
    color: #b91c1c;
}
.ml-verdict.negative {
    background: rgba(16,185,129,0.08);
    border-left-color: #10b981;
    color: #065f46;
}
body.dark-mode .ml-verdict.positive { color: #fca5a5; }
body.dark-mode .ml-verdict.negative { color: #6ee7b7; }
.ml-loading {
    display: flex;
    align-items: center;
    gap: 0.8rem;
    color: var(--text-secondary);
    font-size: 0.95rem;
    padding: 1rem 0;
}
.ml-loading-spinner {
    width: 20px; height: 20px;
    border: 2px solid var(--border-color);
    border-top-color: var(--primary-color);
    border-radius: 50%;
    animation: spin 0.7s linear infinite;
}
@keyframes spin { to { transform: rotate(360deg); } }

/* ── WGCNA cell-type ORA cards ── */
.cell-type-card {
    display: inline-flex;
    flex-direction: column;
    align-items: center;
    padding: 0.5rem 0.8rem;
    border-radius: 8px;
    background: var(--bg-secondary);
    border: 1.5px solid var(--border-color);
    font-size: 0.8rem;
    font-weight: 600;
    margin: 0.25rem;
    transition: transform 0.2s;
}
.cell-type-card:hover { transform: translateY(-2px); }
.cell-type-card .ct-name { color: var(--text-secondary); margin-bottom: 0.2rem; }
.cell-type-card .ct-p { font-family: 'JetBrains Mono', monospace; font-size: 0.75rem; }